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KMID : 0613820020120030281
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Journal of Life Science
2002 Volume.12 No. 3 p.281 ~ p.287
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Biotransformation of Arylnitroso Compound by Mammalian 1,4-Benzoquinone Reductase
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Kim Kyung-Soon
Shin Hae-Yong
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Abstract
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Quinone reductase was purified to homogeneity from bovine liver and the purified enzyme catalyzed the reduction of phenanthrenequinone as well as benzo- and naphthoquinones. The enzyme catalyzed the biotransformation of arylnitroso nitroso compound and the reaction product was identified by TLC, GC, GC-MS and NMR. The reaction was almost entirely inhibitable by Cibacron blue 3GA or dicumarol, potent inhibitors of mammalian quinone reductase.
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KEYWORD
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arylnitroso nitroso compound, biotransformation, enzyme
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